Engineering haploidentical transplants

Tissue engineering of biphasic joint cartilage transplants.

In isolated posttraumatic or idiopathic joint defects the chondral layers and adjacent subchondral spongy bone are usually destructed. For regeneration we suggest the in vitro formation of a cartilage-coated biomaterial carriers (biphases) in order to fill the correspondingjoint defects. In this study Biocoral, a natural coralline material made of calcium carbonate, and calcite, a synthetic cal...

Haploidentical transplantation in children.

Tirado et al are puzzling in view of the elevated IgE levels in WAS patients,7 considering that IgE production is dependent on IL-4. If Th2 cells are deficient in IL-4 secretion, where does IL-4 come from? Morales-Tirado et al show that basophils and the minor T-cell subpopulation T cells can produce IL-4 in a manner independent of WASp. They propose that these cells are responsible for IL-4 pr...

T-cell-replete haploidentical transplantation versus autologous stem cell transplantation in adult acute leukemia: a matched pair analysis.

Adult patients with acute leukemia in need of a transplant but without a genoidentical donor are usually considered upfront for transplantation with stem cells from any other allogeneic source, rather than autologous stem cell transplantation. We used data from the European Society for Blood and Marrow Transplantation and performed a matched pair analysis on 188 T-cell-replete haploidentical an...

Selecting the best haploidentical donor.

The substantial evidence of the safety of human leukocyte antigen (HLA)-haploidentical (haplo) blood or marrow transplantation (BMT) has led to its increasing utilization. When prioritizing HLA-matched grafts, patients frequently have few or no donors from whom to choose. However, a given patient may have multiple suitable haplo donors. Therefore factors other than HLA-match become critical for...

Cellular transplants.